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Extracellular Vesicles and Coagulation

Coagulation is an important process that makes the blood cloth. It stops the damaged blood vessel from bleeding but is also involved in clothing the blood vessels providing blood to the heart or brain leading to a heart attack or stroke.

Coagulation can be activated in several ways but Tissue Factor is a very important activator of blood clothing.

Recently it was found that the blood contains Tissue Factor and that this Tissue Factor is found in blood extracellular vesicles that, among others, originate from monocytes. This identifies extracellular vesicles as an important determinant in blood coagulation in physiological but also pathological processes.