SOCRATES Executives

A/Prof Toh Wei Seong
Academic Appointment:
- Associate Professor
Department of Orthopaedic Surgery
Yong Loo Lin School of Medicine
National University of Singapore - Deputy Research Director
Department of Orthopaedic Surgery
Yong Loo Lin School of Medicine
National University of Singapore - Associate Professor (Joint)
Faculty of Dentistry,
National University of Singapore - Associate Professor (Courtesy)
Department of Biomedical Engineering,
Faculty of Engineering,
National University of Singapore - Principal Investigator
NUS Tissue Engineering Programme (NUSTEP),
Life Science Institute,
National University of Singapore - Supervisor
Integrative Sciences and Engineering Program,
NUS Graduate School
National University of Singapore
Qualifications
- Post-Doc, Harvard Medical School, USA
- PhD, National University of Singapore, Singapore
- MSc, National University of Singapore, Singapore
- BSc, University of Melbourne, Australia
Awards and Prizes
- World’s Top 2% Scientists, Stanford University, USA, 2021
- AUA Scholars Award, Asian Universities Alliance, 2019
- Young Scientist Award, 9th World Biomaterials Congress, China, 2012
- A*STAR International Fellowship Award, Agency for Science, Technology and Research (A*STAR) Singapore, 2010 – 2012
- President Graduate Fellowship Award, National University of Singapore, Singapore, 2006 – 2010
- Dental Science Poster Award, Combined Scientific Meeting, Singapore, 2005
- NUS Research Scholarship, National University of Singapore, Singapore, 2004 – 2010
- Research Summer Scholarship, Peter MacCallum Cancer Centre, Australia, 2003
- Singapore Association for Medical Laboratory Science Prize, Singapore Polytechnic, Singapore, 1999
Research Areas of Interests
- Musculoskeletal Research, Innovation and Translation
- Our research activities are focused on understanding the mechanisms for degeneration, and developing strategies for regeneration, of tissues of the musculoskeletal system.
Selected Research Projects
- Translating MSC exosomes into pharmaceuticals
- Exosome-infused device for enhanced spinal fusion
- MSC exosomes: the next-generation MSC therapy for treatment of cartilage injuries
A/Prof Toh Wei Seong’s Selected Publications
- Mesenchymal stem cell exosomes promote functional osteochondral repair in a clinically relevant porcine model.
The American Journal of Sports Medicine 50(3): 788-800.
Zhang S, Wong KL, Ren XF, Teo KYW, Afizah H, Choo AB, Lai RC, Lim SK, Hui JH, Toh WS. (2022) - Intra-articular injections of mesenchymal stem cell exosomes and hyaluronic acid improve structural and mechanical properties in repaired cartilage in a rabbit model.
Arthroscopy – The Journal of Arthroscopic and Related Surgery 36(8): 2215-2228.
Wong KL, Zhang S, Wang M, Ren XF, Afizah H, Lai RC, Lim SK, EH Lee, Hui JH, Toh WS. (2020) - Equivalent 10-year outcomes after implantation of autologous bone marrow-derived mesenchymal stem cells versus autologous chondrocyte implantation for chondral defects of the knee.
The American Journal of Sports Medicine 47(12): 2881-2887.
Teo AQ, Wong KL, Shen L, Lim JY, Toh WS, Lee EH, Hui JH. (2019) - Mesenchymal stem cell exosomes enhance periodontal ligament cell functions and promote periodontal regeneration.
Acta Biomaterialia 89: 252-264.
Chew JR, Chuah SJ, Teo KYW, Zhang S, Lai RC, Fu JH, Lim LP, Lim SK, Toh WS. (2019) - MSC exosomes alleviate temporomandibular joint osteoarthritis by attenuating inflammation and restoring matrix homeostasis.
Biomaterials 200: 35-47.
Zhang S, Teo KYW, Chuah SJ, Lai RC, Lim SK, Toh WS. (2019) - Substrate stiffness modulates the multipotency of neural crest derived human ectomesenchymal stem cells via CD44 mediated PDGFR signaling.
Biomaterials 167: 153-167.
Srinivasan A, Chang SY, Zhang S, Toh WS, Toh YC. (2018) - MSC exosomes mediate cartilage repair by enhancing proliferation, attenuating apoptosis and modulating immune reactivity.
Biomaterials 156: 16-27.
Zhang S, Chuah SJ, Lai RC, Hui JH, Lim SK, Toh WS. (2018) - Distribution of pericellular matrix molecules in temporomandibular joint and their chondroprotective effects against inflammation.
International Journal of Oral Science 9(1): 43-52.
Chu WC, Zhang S, Sng TJ, Ong YJ, Tan WL, Ang VY, Foldager CB, Toh WS. (2017) - Exosomes derived from human embryonic mesenchymal stem cells promote osteochondral regeneration.
Osteoarthritis and Cartilage 24(12): 2135-2140.
Zhang S, Chu WC, Lai RC, Lim SK, Hui JH, Toh WS. (2016) - Adipose tissue and extracellular matrix development by injectable decellularized adipose matrix loaded with basic fibroblast growth factor.
Plastic and Reconstructive Surgery 137(4): 1171-1180.
Zhang S, Lu Q, Cao T, Toh WS. (2016)