SOCRATES Executives

A/Prof Toh Wei Seong


Academic Appointment:

  • Associate Professor
    Department of Orthopaedic Surgery
    Yong Loo Lin School of Medicine
    National University of Singapore
  • Deputy Research Director
    Department of Orthopaedic Surgery
    Yong Loo Lin School of Medicine
    National University of Singapore
  • Associate Professor (Joint)
    Faculty of Dentistry,
    National University of Singapore
  • Associate Professor (Courtesy)
    Department of Biomedical Engineering,
    Faculty of Engineering,
    National University of Singapore
  • Principal Investigator
    NUS Tissue Engineering Programme (NUSTEP),
    Life Science Institute,
    National University of Singapore
  • Supervisor

    Integrative Sciences and Engineering Program,
    NUS Graduate School
    National University of Singapore



  • Post-Doc, Harvard Medical School, USA
  • PhD, National University of Singapore, Singapore
  • MSc, National University of Singapore, Singapore
  • BSc, University of Melbourne, Australia


Awards and Prizes

  • World’s Top 2% Scientists, Stanford University, USA, 2021
  • AUA Scholars Award, Asian Universities Alliance, 2019
  • Young Scientist Award, 9th World Biomaterials Congress, China, 2012
  • A*STAR International Fellowship Award, Agency for Science, Technology and Research (A*STAR) Singapore, 2010 – 2012
  • President Graduate Fellowship Award, National University of Singapore, Singapore, 2006 – 2010
  • Dental Science Poster Award, Combined Scientific Meeting, Singapore, 2005
  • NUS Research Scholarship, National University of Singapore, Singapore, 2004 – 2010
  • Research Summer Scholarship, Peter MacCallum Cancer Centre, Australia, 2003
  • Singapore Association for Medical Laboratory Science Prize, Singapore Polytechnic, Singapore, 1999


Research Areas of Interests

  • Musculoskeletal Research, Innovation and Translation
    • Our research activities are focused on understanding the mechanisms for degeneration, and developing strategies for regeneration, of tissues of the musculoskeletal system.


Selected Research Projects

  • Translating MSC exosomes into pharmaceuticals
  • Exosome-infused device for enhanced spinal fusion
  • MSC exosomes: the next-generation MSC therapy for treatment of cartilage injuries


A/Prof Toh Wei Seong’s Selected Publications

  • Mesenchymal stem cell exosomes promote functional osteochondral repair in a clinically relevant porcine model.
    The American Journal of Sports Medicine 50(3): 788-800.
    Zhang S, Wong KL, Ren XF, Teo KYW, Afizah H, Choo AB, Lai RC, Lim SK, Hui JH, Toh WS. (2022)
  • Intra-articular injections of mesenchymal stem cell exosomes and hyaluronic acid improve structural and mechanical properties in repaired cartilage in a rabbit model.
    Arthroscopy – The Journal of Arthroscopic and Related Surgery 36(8): 2215-2228.
    Wong KL, Zhang S, Wang M, Ren XF, Afizah H, Lai RC, Lim SK, EH Lee, Hui JH, Toh WS. (2020)
  • Equivalent 10-year outcomes after implantation of autologous bone marrow-derived mesenchymal stem cells versus autologous chondrocyte implantation for chondral defects of the knee.
    The American Journal of Sports Medicine 47(12): 2881-2887.
    Teo AQ, Wong KL, Shen L, Lim JY, Toh WS, Lee EH, Hui JH. (2019)
  • Mesenchymal stem cell exosomes enhance periodontal ligament cell functions and promote periodontal regeneration.
    Acta Biomaterialia 89: 252-264.
    Chew JR, Chuah SJ, Teo KYW, Zhang S, Lai RC, Fu JH, Lim LP, Lim SK, Toh WS. (2019)
  • MSC exosomes alleviate temporomandibular joint osteoarthritis by attenuating inflammation and restoring matrix homeostasis.
    Biomaterials 200: 35-47.
    Zhang S, Teo KYW, Chuah SJ, Lai RC, Lim SK, Toh WS. (2019)
  • Substrate stiffness modulates the multipotency of neural crest derived human ectomesenchymal stem cells via CD44 mediated PDGFR signaling.
    Biomaterials 167: 153-167.
    Srinivasan A, Chang SY, Zhang S, Toh WS, Toh YC. (2018)
  • MSC exosomes mediate cartilage repair by enhancing proliferation, attenuating apoptosis and modulating immune reactivity.
    Biomaterials 156: 16-27.
    Zhang S, Chuah SJ, Lai RC, Hui JH, Lim SK, Toh WS. (2018)
  • Distribution of pericellular matrix molecules in temporomandibular joint and their chondroprotective effects against inflammation.
    International Journal of Oral Science 9(1): 43-52.
    Chu WC, Zhang S, Sng TJ, Ong YJ, Tan WL, Ang VY, Foldager CB, Toh WS. (2017)
  • Exosomes derived from human embryonic mesenchymal stem cells promote osteochondral regeneration.
    Osteoarthritis and Cartilage 24(12): 2135-2140.
    Zhang S, Chu WC, Lai RC, Lim SK, Hui JH, Toh WS. (2016)
  • Adipose tissue and extracellular matrix development by injectable decellularized adipose matrix loaded with basic fibroblast growth factor.
    Plastic and Reconstructive Surgery 137(4): 1171-1180.
    Zhang S, Lu Q, Cao T, Toh WS. (2016)